The difference between honorific and humble speech is particularly pronounced in the Japanese language. Humble language is used to talk about oneself or one's own group (company, family) whilst honorific language is mostly used when describing the interlocutor and their group. For example, the -san suffix ("Mr" "Mrs." or "Miss") is an example of honorific language. It is not used to talk about oneself or when talking about someone from one's company to an external person, since the company is the speaker's "group". When speaking directly to one's superior in one's company or when speaking with other employees within one's company about a superior, a Japanese person will use vocabulary and inflections of the honorific register to refer to the in-group superior and their speech and actions. When speaking to a person from another company (i.e., a member of an out-group), however, a Japanese person will use the plain or the humble register to refer to the speech and actions of their own in-group superiors. In short, the register used in Japanese to refer to the person, speech, or actions of any particular individual varies depending on the relationship (either in-group or out-group) between the speaker and listener, as well as depending on the relative status of the speaker, listener, and third-person referents.

Most nouns in the Japanese language may be made polite by the addition of o- or go- as a prefix. o- is generally used for words of native Japanese origin, whereas go- is affixed to words of Chinese derivation. In some cases, the prefix has become a fixed part of the word, and is included even in regular speech, such as gohan 'cooked rice; meal.' Such a construction often indicates deference to either the item's owner or to the object itself. For example, the word tomodachi 'friend,' would become o-tomodachi when referring to the friend of someone of higher status (though mothers often use this form to refer to their children's friends). On the other hand, a polite speaker may sometimes refer to mizu 'water' as o-mizu in order to show politeness.

Most Japanese people employ politeness to indicate a lack of familiarity. That is, they use polite forms for new acquaintances, but if a relationship becomes more intimate, they no longer use them. This occurs regardless of age, social class, or gender.